Robert Koch-Institut - Robert Koch-Institute, Nachwuchsgruppe 2
The junior research group 2 utilizes mass spectrometry and microscopy-based approaches to investigate the metabolism of protozoan pathogens, with a strong focus on Toxoplasma gondii. In particular we are interested in persistent stages of the parasite.
Die Nachwuchsgruppe 2 benutzt massenspektrometrische und mikroskopische Methoden um den Stoffwechsel von pathogene Mikroben, insbesondere Toxoplasma gondii's zu untersuchen. Von speziellem Interesse sind dabei persistente Stadien.
2 PhD positions in parasite metabolomics
We are offering two PhD positions in parasite metabolomics to start at the earliest possible date.
Chronic infections with bacterial, fungal and parasite pathogens that evade current medical treatments are a mounting problem for the public health. Toxoplasma gondii causes untreata-ble chronic infections in 30% of humans world-wide. We use this protozoan as a model to in-vestigate metabolic mechanisms that enable persistence and to identify novel intervention strategies.
We are developing state-of-the-art metabolomics platform (LCMS and GCMS) for global and untargeted analysis of parasite metabolism. These mass spectrometry-based approaches are complemented with single cell-resolved microscopic analyses and reverse-genetic methods.
In vitro cultivation of T. gondii parasites and reverse genetic manipulation of T. gondii para-sites (CRISPR, knock-out, knock-in)
mass spectrometry-based analysis of metabolites (untargeted LCMS und targeted GCMS)
Life - cell imaging, molecular biology methods
Publication and presentation of research results
A completed university degree (Masters, Diploma, Honours) in the field of life sciences, preferably biology, biochemistry, biotechnology or biophysics, which qualifies you to complete a PhD
Previous exposure to mass spectrometry, life - cell imaging with respective data analysis methods and molecular biological methods are advantageous
Solid skills in MS-Office applications or equivalent are required; knowledge in R und Python are welcomed
Required language skills (CEFR-level): advanced knowledge of English (at least C1). Although no German skills are required, applicants will be encouraged to develop such skills to maxim-ize their integration in our institute.
You should have a proven interest in metabolism. You are also able to independently formulate scientific questions and develop experimental approaches. You have the ability to quickly take up new tasks and work independently with appropriate supervision to meet objectives. You’re open-minded and seize opportunities to network within and outside the institute.
What we offer:
We are offering the following positions in our Junior Research Group 2 for two
Doctoral Candidates (PhD positions m/f, 50 %, public sector wage scale TVöD grade 13)
for a fixed term of two years with the option of extension for a third year, starting at the earliest possible opportunity. The position is part-time to allow an opportunity for independent research dedicated to comple-tion of doctoral work. Berlin offers a wide range of PhD programs providing weekly talks by international speakers and many opportunities to interact with fellow students. Positions are equipped with travel funds and one student research assistant each.
How to apply:
Submit your application via the public service job portal Interamt at www.interamt.de by 7. August 2017. Please note the position identification number: 397506 (StellenID)/ Kz. 78/17.
If you have questions about the application procedure, please contact Katharina Brandt (Tel.: +49 30 18754 2812 E-Mail: BrandtK[at]rki.de) and the Junior group leader Dr. Martin Blume (+49 30 18754 2572 blumem[at]rki.de).