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An­ge­bot 131 von 471 vom 13.11.2017, 12:27

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Cha­rité-Uni­ver­si­täts­me­di­zin Ber­lin - Ber­lin-Bran­den­burg Cen­ter for Rege­ne­ra­tive The­ra­pies

Das BCRT wurde 2006 als Alli­anz der Cha­rité-Uni­ver­si­täts­me­di­zin Ber­lin und der Helm­holtz-Gemein­schaft gegrün­det. Mehr als 250 Mit­ar­bei­ter – Ärzte, Natur­wis­sen­schaft­ler, Trans­la­ti­ons­ex­per­ten, Inge­nieure, Dok­to­ran­den und tech­ni­sche Mit­ar­bei­ter – for­schen und arbei­ten an den zwei Stand­or­ten des BCRT: am Insti­tuts­ge­bäude Süd des Cam­pus Vir­chow-Kli­ni­kum der Cha­rité und am Cam­pus Tel­tow des Insti­tuts für Bio­ma­te­ri­al­for­schung der Helm­holtz-Zen­trums Geest­hacht GmbH.

MAS­TER THESIS PRO­POSAL

Micro Finite Ele­ment Mod­els of the human femoral neck

Work­ing field:

DESCRIP­TION: With the advent of mod­ern scan­ners, mul­ti­di­men­sional, high-res­ol­u­tion com­puted tomo­graphy (CT) images are becom­ing avail­able to clini­cians and bio­med­ical research­ers for the assess­ment of human bone fra­gil­ity. 3D CT data can be util­ized for gen­er­at­ing Finite Ele­ment Mod­els (FEM) of the prox­imal femur in order to sim­u­late the mech­an­ical response of the hip under sev­eral load­ing con­di­tions. However, mesh size is often con­strained by the res­ol­u­tion of the input data and by com­pu­ta­tion cost, thus lim­it­ing the model abil­ity to rep­res­ent struc­tural fea­tures below the mm length scale.
Within a mul­ti­cen­ter study we have acquired CT data of entire human prox­imal femur samples at unpre­ced­en­ted res­ol­u­tion.

Require­ments:

Aim of this mas­ter thesis is the devel­op­ment of a micro-FEM model of the human femoral neck, being this the most import­ant frac­ture site in the eld­erly pop­u­la­tion. The model will allow to invest­ig­ate the rela­tion­ship between the bone micro-struc­ture and its mech­an­ical com­pet­ence. The stu­dent will learn the basic con­cepts of bone bio­mech­an­ics, bio­med­ical 3D ima­ging and FE ana­lysis.

REQUIRE­MENTS: basic pro­gram­ming know­ledge is required

What we of­fer:

To work in an inter­na­tional inter­dis­cip­lin­ary reseearch Envir­on­ment.

How to ap­ply:

Send your applic­a­tion includ­ing your CV to Prof. Kay Raum (kay.raum@charite.de)