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Tech­ni­sche Uni­ver­si­tät Dres­den - Cen­ter for Mole­cu­lar and Cel­lu­lar Bio­en­gi­nee­ring (CMCB), Cen­ter for Rege­ne­ra­tive The­ra­pies Dres­den (CRTD), Chair of Stern Cell Rese­arch with Focus on cell-based Approa­ches to Rege­ne­ra­tive Bio­me­di­cine

The TU Dres­den is one of ele­ven Ger­man uni­ver­si­ties that were iden­ti­fied as an “excel­lence uni­ver­sity”. TUD has about 36.500 stu­dents and almost 5319 employees, 507 pro­fes­sors among them, and, thus, is the lar­gest uni­ver­sity in Sax­ony, today.

Having been com­mit­ted to sci­en­ces and the engi­nee­ring before the reuni­fi­ca­tion of Ger­many, TU Dres­den now is a multi-disci­pline uni­ver­sity, also offe­ring huma­nities and social sci­en­ces as well as medi­cine.

Rese­arch Asso­ciate / Post­doc

(Sub­ject to per­so­nal qua­li­fi­ca­tion, employees are remu­ne­ra­ted up to salary group E13 TV-L)
The pro­ject posi­tion is pro­s­pec­tively star­ting on 01. Novem­ber 2019. The posi­tion, offe­red in the con­text of the ERC pro­ject MacA­ge­Ma­cro­phage aging and reju­ve­na­tion, is initi­ally limi­ted until 31. Decem­ber 2021 (with the option to be exten­ded). The period of employ­ment is gover­ned by the Fixed Term Rese­arch Con­tracts Act (Wis­sen­schafts­zeit­ver­trags­ge­setz - WissZeitVG). The posi­tion aims at obtai­ning fur­ther aca­de­mic qua­li­fi­ca­tion.
The rese­arch focus of the chair is to gain new insights into the regu­latory mecha­nisms gover­ning the self-rene­wal, dif­fe­ren­tia­tion and aging of macro­pha­ges (Aziz et al., Sci­ence 2009, Sie­weke and Allen, Sci­ence 2013, Molawi et al., JEM 2014, Sou­cie et al, Sci­ence 2016, Matco­vitch-Natan et al., Sci­ence 2016, lmpe­ra­tore et al, EMBO J. 2017, Mos­sa­degh-Kel­ler et al., JEM 2017). The group uses a broad spec­trum of mole­cu­lar, gene­tic, his­to­lo­gi­cal and ima­ging tech­ni­ques in com­bi­na­tion with in vivo and in cul­ture model sys­tems. Fur­ther infor­ma­tion: https://www.crt-dresden.de/research/research-groups/core-groups/crtd-core-groups/sieweke-stem-cell-and-macrophage-biology/ and http://www.ciml.univ-mrs.fr/science/lab-michael-sieweke/stem-cell-and-macrophage-biology-O
The CRTD is one of the world's lea­ding Rege­ne­ra­tive Bio­Me­di­cine cen­tres and forms the inter­face bet­ween basic rese­arch and cli­ni­cal app­li­ca­tion. The aim of the CRTD is to inves­ti­gate the body's self-healing poten­tial and to deve­lop com­ple­tely new rege­ne­ra­tive the­ra­pies for pre­viously incura­ble disea­ses. The posi­tion pro­vi­des ample oppor­tu­nity to inter­act with other rese­ar­chers in rege­ne­ra­tive medi­cine, immu­no­logy, cell bio­logy, sys­tems bio­logy and bio­tech­no­logy at the CRTD and neigh­bou­ring insti­tu­tes on the cam­pus. Rese­arch areas include haema­to­logy and immu­no­logy, dia­be­tes, neu­ro­de­ge­ne­ra­tive disea­ses, bone and car­ti­lage repla­ce­ment as weil as car­dio­vascu­lar disea­ses, lung and liver rege­ne­ra­tion. Rese­arch at CRTD is sup­por­ted by access to high end plat­forms on flow cyto­me­try, advan­ced ima­ging, deep sequen­cing and genome engi­nee­ring, among others, through the joint tech­no­logy plat­form of the CMCB (infor­ma­tion on the joint tech­no­logy plat­form is avail­able at http://biotp.tu-dresden.de/biotechnology-platform/).

Work­ing field:

The aim of the post-doc­to­ral pro­ject will be to use mouse-gene­tics and geno­mics approa­ches to under­stand self-rene­wal, aging and repli­ca­tive sen­e­scence mecha­nisms in macro­pha­ges and their impact on the health of the sur­roun­ding tis­sue of resi­dence. The pro­ject will use exis­ting or newly deve­lo­ped rele­vant mouse models to ana­lyse genome wide chan­ges in epi­ge­ne­tics and gene expres­sion and their influ­ence on resi­dent macro­phage popu­la­ti­ons and the sur­roun­ding tis­sue.

Require­ments:

App­li­ca­ti­ons are invi­ted from highly talen­ted and enthu­si­astic rese­ar­chers with a uni­ver­sity and PhD degree and a strong track record. Evi­dence of one or more high impact publi­ca­ti­ons in a rele­vant rese­arch field and trai­ning in inter­na­tio­nal lea­ding labo­ra­to­ries is a merit.
Pre­vious expe­ri­ence in expe­ri­men­tal app­li­ca­tion of mouse gene­tics, mole­cu­lar and cel­lu­lar bio­logy tech­ni­ques to the study of immu­no­logy, aging or rege­ne­ra­tion is desi­red but app­li­cants with rele­vant expe­ri­ence working in other fields will also be con­si­de­red. App­li­cants should have excel­lent inter­per­so­nal and com­mu­ni­ca­tion skills, orga­ni­za­tio­nal skills to plan expe­ri­men­tal bench-work and the abi­lity to work as part of a team as well as inde­pendently when requi­red. Expe­ri­ence with state-of-the-art flow cyto­me­try and mole­cu­lar ana­ly­sis (RNA and DNA sequen­cing, ChlP­seq) of small cell num­bers inclu­ding sin­gle cells is desi­red. Expe­ri­ence with tis­sue ana­ly­sis and ima­ging is an addi­tio­nal asset. Abi­lity to stay on top of the rele­vant rese­arch field is an abso­lute requi­re­ment as well as good know­ledge of spo­ken and writ­ten Eng­lish. We are loo­king for a highly moti­va­ted, ambi­tious, effec­tive and inter­ac­tive can­di­date capa­ble of lea­ding a high-pro­file rese­arch pro­ject through active pur­suit of rele­vant expe­ri­ments, and through regu­lar inter­ac­tions with the group lea­der and important col­la­bo­ra­tors wit­hin and out­side the rese­arch insti­tute.

How to ap­ply:

App­li­ca­ti­ons from women are par­ti­cu­larly wel­come. The same app­lies to people with disa­bi­li­ties.
Please sub­mit your app­li­ca­tion docu­ments, inclu­ding a let­ter of moti­va­tion describ­ing published and ongo­ing work, CV, let­ter or con­tact for 3 refe­ren­ces and a state­ment of future rese­arch inte­rest until 30.08.2019 (stam­ped arri­val date app­lies) pre­fer­a­bly via the TU Dres­den Secu­re­Mail Por­tal https://securemail.tu-dresden.de as a sin­gle PDF file to jeannette.hoppe@tu-dresden.de or alter­na­tively to: TU Dres­den, CRTD, Frau Jean­nette Hoppe, Fet­scher­straße 105, 01307 Dres­den. Please sub­mit copies only, as your app­li­ca­tion will not be retur­ned to you. Expen­ses incur­red in atten­ding inter­views can­not be reim­bur­sed.

Refe­rence to data pro­tec­tion: Your data pro­tec­tion rights, the pur­pose for which your data will be pro­ces­sed, as well as fur­ther infor­ma­tion ab out data pro­tec­tion is avail­able to you on the web­site: https://tu-dresden.de/karriere/datenschutzhinweis.